Bilateral lateral maxillary sinus lift with bovine xenograft and autologous platelet-rich fibrin: case report and clinical feasibility analysis
DOI:
https://doi.org/10.62331/2965-758X.v3.2025.64Keywords:
Schneider membrane lifting, Maxillary sinus, Xenograft, Platelet-rich fibrin, Bioactive adjuvant, Bone regeneration, ImplantologyAbstract
Post-extraction bone resorption and sinus pneumatization in the posterior maxilla present critical challenges for implant rehabilitation, necessitating regenerative techniques such as maxillary sinus lift (MSL) with biomaterials. This study aimed to report the clinical efficacy of bovine xenograft combined with platelet-rich fibrin (PRF) in bilateral MSL via lateral approach. A 54-year-old female patient with severe bone resorption underwent Schneiderian membrane elevation and grafting with a composite of Cerabone® and autologous PRF into the sub-sinus space. After 6 months, computed tomography confirmed adequate bone consolidation, enabling stable implant placement and resolution of masticatory dysfunction. The combined technique demonstrated feasibility, with satisfactory bone formation and benefits attributable to PRF’s bioactive properties (healing acceleration and vascularization). Literature inconsistencies underscore the need for controlled studies to validate its synergistic osteogenic efficacy.
References
da Silva AJC, Arruda FJS de. Desafios na implantodontia: biomateriais e sua contribuição na reabilitação de maxilas atróficas. Biosciences and Health. 2025; 3:1-7. https://doi.org/10.62331/2965-758X.v3.2025.71
Santos MEC dos, Arruda FJS de. Prótese parcial removível associada a implantes dentários - relato de caso. Biosciences and Health. 2025; 3:1-9. https://doi.org/10.62331/2965-758X.v3.2025.63
Alshamrani AM, Mubarki M, Alsager AS, Alsharif HK, AlHumaidan SA, Al-Omar A. Maxillary sinus lift procedures: an overview of current techniques, presurgical evaluation, and complications. Cureus. 2023; 15(11):e49553. https://doi.org/10.7759/cureus.49553
Andrés-García R, Ríos-Santos JV, Herrero-Climent M, Bullón P, Fernández-Farhall J, Gómez-Menchero A, et al. Sinus floor elevation via an osteotome technique without biomaterials. Int J Environ Res Public Health. 2021; 18(3):1103. https://doi.org/10.3390/ijerph18031103.
Fischer JL, Riley CA, Kacker A. Sinonasal complications following the sinus lift procedure. Ochsner J. 2023; 23(2):147-151. https://doi.org/10.31486/toj.22.0125
Sheikhi M, Haghighat A, Lourizadeh N, Tavangar H, Aryaee P. Evaluation of the effect of direct sinus lift surgery on maxillary sinus volume by Mimics software. Natl J Maxillofac Surg. 2023; 14(2):198-207. https://doi.org/10.4103/njms.njms_155_22
Farias IOB, Bahia RRC, Barreto MA, Pinto FS, Fernandes AC de S. Lateral window maxillary sinus lift surgery: case report. RGO. 2022; 70:e20220031. https://doi.org/10.1590/1981-86372022003120210042
Schiavon L, Perini A, Brunello G, Ferrante G, Del Fabbro M, Botticelli D, et al. The bone lid technique in lateral sinus lift: a systematic review and meta-analysis. Int J Implant Dent. 2022; 8(1):33. https://doi.org/10.1186/s40729-022-00433-3
Virnik S, Cueni L, Kloss-Brandstätter A. Is one-stage lateral sinus lift and implantation safe in severely atrophic maxillae? results of a comparative pilot study. Int J Implant Dent. 2023; 9(1):6. https://doi.org/10.1186/s40729-023-00471-5
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3):299-303. https://doi.org/10.1016/j.tripleo.2005.07.012
Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012; 13(7):1231-56. https://doi.org/10.2174/138920112800624472
Arshad S, Tehreem F, Rehab Khan M, Ahmed F, Marya A, Karobari MI. Platelet-rich fibrin used in regenerative endodontics and dentistry: current uses, limitations, and future recommendations for application. Int J Dent. 2021; 2021:4514598. https://doi.org/10.1155/2021/4514598
Lie SAN, Claessen RMMA, Leung CAW, Merten HA, Kessler PAWH. Non-grafted versus grafted sinus lift procedures for implantation in the atrophic maxilla: a systematic review and meta-analysis of randomized controlled trials. Int J Oral Maxillofac Surg. 2022; 51(1):122-132. https://doi.org/10.1016/j.ijom.2021.03.016
da Silva HF, Goulart DR, Sverzut AT, Olate S, de Moraes M. Comparison of two anorganic bovine bone in maxillary sinus lift: a split-mouth study with clinical, radiographical, and histomorphometrical analysis. Int J Implant Dent. 2020; 6(1):17. https://doi.org/10.1186/s40729-020-00214-w
Jamcoski VH, Faot F, Marcello-Machado RM, Melo ACM, Fontão FNGK. 15-Year retrospective study on the success rate of maxillary sinus augmentation and implants: influence of bone substitute type, presurgical bone height, and membrane perforation during sinus lift. Biomed Res Int. 2023; 2023:9144661. https://doi.org/10.1155/2023/9144661
Miron RJ, Fujioka-Kobayashi M, Sculean A, Zhang Y. Optimization of platelet-rich fibrin. Periodontol 2000. 2024; 94(1):79-91. https://doi.org/10.1111/prd.12521
Damsaz M, Castagnoli CZ, Eshghpour M, Alamdari DH, Alamdari AH, Noujeim ZEF, et al. Evidence-based clinical efficacy of leukocyte and platelet-rich fibrin in maxillary sinus floor lift, graft and surgical augmentation procedures. Front Surg. 2020; 7:537138. https://doi.org/10.3389/fsurg.2020.537138
Baru O, Buduru SD, Berindan-Neagoe I, Leucuta DC, Roman AR, Tălmăceanu D, et al. Autologous leucocyte and platelet rich in fibrin (L-PRF) - is it a competitive solution for bone augmentation in maxillary sinus lift? A 6-month radiological comparison between xenografts and L-PRF. Med Pharm Rep. 2024; 97(2):222-233. https://doi.org/10.15386/mpr-2719
Pardal-Peláez B, Córdoba-Llorente JR, Belarra-Arenas C. Sinus lift through the use of a surgical guide: a case report. Int J Comput Dent. 2020; 23(4):377-386. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33491933/
Otero AIP, Fernandes JCH, Borges T, Nassani L, Castilho RM, Fernandes GVO. Sinus lift associated with leucocyte-platelet-rich fibrin (second generation) for bone gain: a systematic review. J Clin Med. 2022; 11(7):1888. https://doi.org/10.3390/jcm11071888
Egierska D, Perszke M, Mazur M, Duś-Ilnicka I. Platelet-rich plasma and platelet-rich fibrin in oral surgery: a narrative review. Dent Med Probl. 2023; 60(1):177-186. https://doi.org/10.17219/dmp/147298
Dominiak S, Karuga-Kuźniewska E, Popecki P, Kubasiewicz-Ross P. PRF versus xenograft in sinus augmentation in case of HA-coating implant placement: a 36-month retrospective study. Adv Clin Exp Med. 2021; 30(6):633-640. https://doi.org/10.17219/acem/134202
Ortega-Mejia H, Estrugo-Devesa A, Saka-Herrán C, Ayuso-Montero R, López-López J, Velasco-Ortega E. Platelet-rich plasma in maxillary sinus augmentation: systematic review. Materials (Basel). 2020; 13(3):622. https://doi.org/10.3390/ma13030622
Rocha CA, Arantes RVN, Cestari TM, Santos PS, Assis GF, Taga R. Maxillary sinus lift response to platelet-rich plasma associated with autogenous bone, ceramic biphasic HA/β-TCP (70:30), or deproteinized bovine bone. Int J Implant Dent. 2020; 6(1):79. https://doi.org/10.1186/s40729-020-00277-9
Malcangi G, Patano A, Palmieri G, Di Pede C, Latini G, Inchingolo AD, et al. Maxillary sinus augmentation using autologous platelet concentrates (platelet-rich plasma, platelet-rich fibrin, and concentrated growth factor) combined with bone graft: a systematic review. Cells. 2023; 12(13):1797. https://doi.org/10.3390/cells12131797
Wang H, Wang J, Guo T, Ding X, Yu W, Zhao J, et al. The endoscopically assisted transcrestal sinus floor elevation with platelet-rich fibrin at an immediate implantation of periapical lesion site: a case report. Medicine (Baltimore). 2019; 98(27):e16251. https://doi.org/10.1097/MD.0000000000016251
Nguyen XT, Le LN, Do TT, Le KPV. Increasing bone regeneration in maxillary sinus augmentation using platelet-rich fibrin: an interventional pre-post study. J Contemp Dent Pract. 2024; 25(9):814-819. https://doi.org/10.5005/jp-journals-10024-3747
Gasparro R, Di Lauro AE, Campana MD, Rosiello N, Mariniello M, Sammartino G, et al. Effectiveness of autologous platelet concentrates in the sinus lift surgery: findings from systematic reviews and meta-analyses. Dent J (Basel). 2024; 12(4):101. https://doi.org/10.3390/dj12040101
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Copyright (c) 2025 Lucas Romero Trevisan, Farid Jamil Silva de Arruda
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